Pharmaburst® C1
Pharmaburst® is an easy-to-use quick dissolving delivery platform, which can be easily and cost effectively formulated with your active.
Quick dissolve systems currently on the market are relatively complex and expensive compared to Pharmaburst®. The main advantage of the Pharmaburst® system is that it gives you the flexibility to develop your own robust “Quick Dissolve” formulations in-house, at a reasonable cost. Pharmaburst® is a co-processed excipient system with specific excipients, which allows rapid disintegration and low adhesion to punch faces.
Typical Properties of Pharmaburst®:
Bulk Density = 0.450 Carr's index = 16.0 % (Good Flow)
Tapped Density = 0.536 Particle Size = 80 _ – 150 _
A comparative example is detailed below to show the advantage of a Co-processed system (Pharmaburst®) over a blended (un-processed) system, in a cough/cold formulation with 3 actives (Table 1). Table 1
Cough/Cold Formulation
| | Ingredient | %
| mg/Tablet
| Pharmaburst X
| 75.075
| 900.9
| Acetaminophen (94%)
| 14.185
| 170.22
| Pseudoephedrine (60%)
| 2.08
| 24.96
| Dextromthorphan (13%)
| 3.208
| 38.496
| Flavor
| 2
| 24
| Sweetener
| 0.25
| 3
| Citric Acid
| 1
| 12
| Color
| 0.2
| 2.4
| Sodium Stearyl Fumerate
| 2
| 24
| Total
| 100.00
| 1200.0
| | Tooling: 0.6299 inch Comp. Cup | Table Weight: 1200mg
| |
Co-Processed Pharmaburst® system has superior compactibility properties, while delivering rapid disintegration. (Graph 1 & 2) With the un-processed blended system, maximum tablet strengths of only 4kP were achieved before capping/lamination occurred. The processed Pharmaburst® system allowed tablet strengths of over 9kP (over 100% increase!). At high speeds on commercial presses this property becomes crucial in making robust “Quick Dissolve” formulations. What is the correct amount of Pharmaburst® to use?
The quantity of Pharmaburst® required in a formulation will depend on the type of active and the quantity per tablet. Initial studies should be carried out on your potential formulation by varying the Pharmaburst® percentage from 50% to 80%. The impact of reducing the Pharmaburst® may give a faster disintegrating tablet but it may appear to be more “Gritty” to the taste. Pharmaburst® is smooth and creamy and helps to mask the taste and grittiness of the actives. Stability Data of Pharmaburst® Tablets stored in HDPE bottle at 40°C/75%RH Formulation: Cough/Cold (table 1)
| Time (Days)
| Weight (mg)
| Hardness (KP)
| ST DEV | Friability (%) | Disint Time (sec) | STDEV
| 1
| 1204.6
| 5.6
| 0.2
| 0.304
| 42
| 3
| 40
| 1210.8
| 6.4
| 0.1 | 0.406
| 44
| 3.6
| 70
| 1213.7
| 6
| 0.3
| 0.452
| 42
| 7.5
|
The limited stability which is currently available shows that tablets manufactured from Pharmaburst® are stable in terms of tablet strength and disintegration time. 
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