Actimask® Acetaminophen

Taste-Masked Acetaminophen for Patient-Friendly Dosage Forms

Actimask® APAP is SPI Pharma’s advanced taste-masking solution for acetaminophen (paracetamol), engineered to deliver a pleasant mouthfeel and high API loading—ideal for chewables, orally disintegrating tablets (ODTs), sachets, and stick packs. Designed to improve patient compliance and streamline formulation development, Actimask® APAP is the key to making patients better—without the bitter.

 

🔬 Why Choose Actimask® for APAP?

  • Bitter taste, solved. Acetaminophen’s naturally bitter profile can impact patient adherence. Actimask® APAP uses a proprietary aqueous gelatin coating to create a physical barrier that prevents taste detection in the oral cavity.

  • High API assay (~94%) allows for smaller, more manageable tablets—a major advantage over traditional taste-masked materials with lower drug load.

  • Flexible formulation options: Suitable for pediatric and adult populations, and easily incorporated into chewables, ODTs, and stick pack formats.

 

⚙️ Formulation & Processing Benefits

✔️ Direct compression-ready

✔️ Smooth, non-gritty mouthfeel

✔️ ≥95% dissolution in 30 minutes (Q = 80%)

✔️ Mean particle size: ~380 μm

✔️ Excellent flow and compressibility (Carr’s Index ~13)

✔️ Solvent-free manufacturing process

 

🧫 Applications

Actimask® APAP is ideal for formulators looking to improve taste and dose delivery in:

  • Pediatric pain and fever medications

  • OTC acetaminophen-based chewables

  • Orally disintegrating tablets (ODTs)

  • On-the-go powders and stick packs

  • Custom branded generics or private label products

 

🌎 Global Formulation Advantages

Whether you're developing for FDA-regulated pediatric markets, consumer-friendly OTC tablets, or cost-sensitive global regions, Actimask® APAP supports:

  • Regulatory compliance (pharmacopeia-grade ingredients)

  • Patient-centric drug delivery

  • Operational efficiency and ease of scale-up

 

📊 Typical Properties

Attribute Actimask® Acetaminophen
Description White to off-white granules
Average Assay (%) ~94%
Dissolution (%) ≥ 95% in 30 minutes (Q = 80%)
Mean Particle Size (d50) ~380 µm
Bulk Density (g/mL) ~0.65
Tapped Density (g/mL) ~0.75
Carr’s Index ~13

 

🎥 Learn More: Watch the Webinar On Demand

“Actimask® Taste-Masking Webinar RECHARGED!
The Key to Making Patients Better – Without the Bitter”

🎬 Watch the Webinar Now »
Duration: 1 hour, 15 minutes

 

📩 Request a Sample or Contact Us

Ready to explore how Actimask® APAP can transform your next formulation?

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