Mannogem® Mannitol

SPI Pharma is the leading manufacturer of mannitol-based products for the pharmaceutical industry. Our extensive experience in polyol chemistry enables us to offer a wide range of customizable mannitol options for all applications and process requirements.

Key Functional Benefits Include:                        

Compactibility

  • Mannogem Mannitol is a strong and durable binder that exhibits high compactibility and low friability. It is not sensitive to overlubrication and displays high dilution capacity.

Stability

  • Due to its low hygroscopicity, Mannogem Mannitol provides physical and chemical stability of moisture-sensitive actives, especially APIs sensitive to hydrolysis. Additionally, Mannogem does not undergo the Maillard reaction in the presence of amines.

Solubility

  • Mannogem Mannitol products dissolve rapidly and can increase the rate of tablet disintegration and drug release. They can help accelerate tablet disintegration and subsequent drug dissolution.

Product Name

Target Application

Particle Size d(0.5)

Dosage Forms

Mannogem Powder

  • Wet granulation
  • Extrusion
  • Spheronization
  • Lyophilization
  • Liquid preparations

≈60µm

  • All Tablet forms
  • Lyoc Tablets
  • Specially designed for drug layering PPI pellets

Mannogem Granular

Mannogem 2080

  • Direct compression
  • Roller compaction with micronized API
  • Dissolution enhancement in swallow tablets

≈400µm

≈300µm

  • Swallow tablets
  • Lozenges
  • Chewable tablets
  • Sachets

Mannogem EZ Spray-Dried

  • Direct compression

≈140µm

  • Swallow tablets
  • Low dosage forms
    (triturating with low dose actives)
  • Lozenges
  • Chewable tablets
  • Sachets

Related Applications

Excipients for Swallow Tablets

Excipients for Swallow Tablets

Traditional swallow tablets are the most widely used solid oral dosage form. Their main advantages are ease of formulation and good chemical and physical stability. They tend to be the most economical to produce.

Excipients for Chewable Tablets and Lozenges

Excipients for Chewable Tablets and Lozenges

Chewable tablets and lozenges are often a preferred dosage form for children and adults who cannot swallow traditional tablets. Ideally these dosage forms should have a smooth, creamy texture and a pleasant taste.

Excipients for Effervescents

Excipients for Effervescents

Effervescence has been widely used in the pharmaceutical and nutritional markets. These delivery systems can provide various benefits ranging from ease and convenience of administration to providing more accurate dosing.

Ingredients for Nutraceuticals

Ingredients for Nutraceuticals

Highly engineered materials and expertise in functional core excipients have made us a valued partner in the formulation of dietary supplements and nutritional products. Our products help you achieve superior organoleptic properties.

Related Resources

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