ACTILLETS™ Microcrystalline Cellulose Pellets

Sometimes, the smallest details make the biggest difference.

	ACTILLETS 100 MCC	ACTILLETS 150 MCC	ACTILLETS 200 MCC	ACTILLETS 350 MCC	ACTILLETS 500 MCC	ACTILLETS 700 MCC	ACTILLETS 1000 MCC
Particle size distribution (≥ 85 %)	100-200 µm	150-300 µm	200-355 µm	350-500 µm	500-710 µm	700-1000 µm	1000-1400 µm

Product Features	Formulation Benefits
Micropellets (100 - 200 µm) for highly active low dose API	Simplified and homogeneous drug coating and control
Wide range of particle size fractions	Easy taste-masking of the final drug
Narrow particle size distribution within each fraction	Application in multiple unit pellet systems (MUPS)
Uniform spherical shape and structure	Application in drug formulations for paediatrics
Made under GMP conditions with MCC from certified suppliers	Better customer acceptance and safety
Quality analyzed according to Ph.Eur., USP/NF and JPE	Reduced food effect, variability and dose dumping
Almost in-soluble in water	High control on time and place of drug delivery
High abrasion resistance	Perfect tool for combinatory and controlled release products
Ideal for capsules	Formulation of sensitive actives due to the inertness of MCC
Excellent compactibility due to the high plasticity	Higher payload permits smaller capsule sizes

Additional Properties

Loss on drying Ph.Eur., USP/NF, JP, JPE	≤ 7.0 %
Bulk density (g/m3) Ph.Eur., USP/NF, JP	0.80 g/m3 ± 5 % (for information only)
Sphericity degree Cellets Standard (average)	≥ 0.90
Friability, Cellets Standard	0 %
Swelling index, Cellets Standard	≤ 2 mL/g
Identification infrared absorption Ph.Eur., USP/NF, JP	passed
Identification zinc chloride test Ph.Eur., USP/NF, JP, JPE	passed
Degree of polymerization Ph.Eur., USP/NF, JP	≤ 350
pH value Ph.Eur., USP/NF, JP, JPE	5.0 – 7.5
Conductivity Ph.Eur., USP/NF, JP, JPE	≤ 75 µS/cm
Ether soluble substances Ph.Eur., USP/NF, JP, JPE	≤ 0.05 %
Water soluble substances Ph.Eur., USP/NF, JP, JPE	≤ 0.25 %
Heavy metals JP, JPE	≤ 10 ppm
Sulfated ash / Residue on ignition Ph.Eur., USP/NF (determined on 1g)	≤ 0.1 %
Sulfated ash / Residue on ignition JP, JPE (determined on 2g)	≤ 0.1 %
Total aerobic microbial count Ph.Eur., USP/NF, JP, JPE	≤ 1,000 CFU/g
Fungi / moulds and yeasts Ph.Eur., USP/NF, JP, JPE	≤ 100 CFU/g
E. coli Ps. aerugin. St. aureus Ph.Eur., USP/NF, JP, JPE	absence in 1 g sample
Salmonella species Ph.Eur., USP/NF, JP, JPE	absence in 10 g sample

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