Mannogem™ XL Series
The superhero excipient for modern formulation challenges.
One excipient. Multiple formulation solutions.
The Mannogem™ XL Series is SPI Pharma’s portfolio of enhanced, fully compendial mannitol excipients designed to solve today’s pharmaceutical and nutraceutical formulation challenges.
Engineered for multifunctional performance, the XL Series acts as a true formulation superhero—helping teams create stronger, smaller, faster‑disintegrating tablets while simplifying formulation design across a wide range of dosage forms.
Engineered for multifunctional performance, the XL Series acts as a true formulation superhero—helping teams create stronger, smaller, faster‑disintegrating tablets while simplifying formulation design across a wide range of dosage forms.
Why Mannogem™ XL Series
Multifunctional performance across the entire portfolio delivering:
- Multifunctional binder + diluent performance
- Higher tabletability vs. standard mannitols
- Faster disintegration for better patient/consumer experience
- Reduced excipient count → simpler formulations
- Higher active loading → smaller, more efficient tablets
- Broad utility across Pharma and Nutra
Meeting the needs of a diverse market
For Pharmaceutical Developers
Performance-driven excipients for modern pharmaceutical challenges
The Mannogem™ XL Series delivers superior tabletability, faster disintegration, and multifunctional performance to help pharmaceutical developers simplify formulations, accelerate development, and improve manufacturing robustness — all within a fully compendial framework.
- Higher tensile strength at lower compression forces
- Faster disintegration without excess disintegrant
- Reduced formulation complexity
- Broad design space for scale-up and commercial manufacturing
For Nutraceutical Innovators
Smaller tablets. Better taste. Faster time to market.
The Mannogem® XL Series enables nutraceutical formulators to create smaller, better-tasting, consumer-friendly tablets while simplifying formulations and reducing development time — without compromising productivity.
- Improved mouthfeel and rapid disintegration
- Higher active loading for trend-driven formulations
- Versatility across chewables, ODTs, and effervescents
- Faster development with greater manufacturing efficiency
- Improved yields and reduced risk during scale-up
Meet our Athletes
Mannogem™ XL
A true multifunctional DC excipient that combines binder + filler performance, enabling simplified formulations and higher active loading in standard direct compression applications.
Differentiating Benefits
- Combines binder and filler functionality → reduces excipient count
- Enables higher loading for smaller tablets
- Ideal for straightforward DC formulations needing simplicity + strength
- Strong tablets without sacrificing disintegration
Mannogem™ XL Opal
A spray‑dried mannitol with enhanced tabletability and a broad compression force window, delivering superior robustness, mouthfeel, and reduced development risk.
Differentiating Benefits
- Wide compression range → highly robust across equipment and speeds
- Spray‑dried mouthfeel with improved manufacturability
- Faster disintegration with less disintegrant
- Best suited for chewables, ODTs, and consumer‑focused formats
Mannogem™ XL Ruby
A next‑generation granular mannitol offering exceptional compressibility and enhanced uniformity, especially for high‑load and segregation‑prone formulations.
Differentiating Benefits
- Highest compressibility of the portfolio (granular → near spray‑dried performance)
- Improved blend uniformity with challenging or large‑particle actives
- Ideal for high‑strength tablets and complex formulations
- Versatile across chewables, lozenges, ODTs, and high‑load formats