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  • Antacid Actives

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The key to making patients better—without the bitter!

The success of your orally administered tablet may depend on how easy and pleasant it is for patients to take. At SPI Pharma, we understand the complex relationship between the taste of active pharmaceutical ingredients (APIs) and their chemical properties. If a tablet has a bitter or unpleasant taste, it can lead to patient noncompliance or even a failed product launch. That’s why taste-masking is an essential part of our product development process. 

There are several challenges when taste-masking a drug. When the simple addition of flavors and sweeteners fail to do the trick, one must consider the addition of a physical barrier around the drug particle to prevent direct contact with the taste buds on the tongue. The coating must be solid enough to mask the taste in the buccal cavity, but also not interfere with the release of the drug in the GI track. Finding the balance between dissolution and taste masking of the drug is not easy and requires expertise.

Our range of drug taste-masking technology includes coacervation and gradient coating, along with ion complexation. Some of the critical aspects of a drug that we take into account when developing a taste-making approach are:

  • Bitterness
  • Dose
  • Particle size
  • Particle shape
  • Ionic characteristic
  • Solubility

The next challenge is to formulate the taste-masked drug into a solid dose form with acceptable organoleptic properties. Our range of taste-masking formulation development includes the incorporation of our highly functional excipients along with our co-processed delivery systems. For more information on how we can help taste-mask your active ingredient:

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