Advantose™ 100

Advantose 100 is a spray-dried maltose powder that provides excellent flow, solubility, and tableting properties for oral dosage formulations. Maltose is well known for its safety and mouthfeel qualities, especially in chewable tablets and lozenges.

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Maltose powder for direct compression

Advantose 100 maltose powder is a spray dried disaccharide carbohydrate. The safety and mouthfeel qualities of maltose are well-known. Now, by spray drying, the flow and tableting properties are greatly improved.

Advantose 100's spray-dried particles are spherical and the combination of fine and coarse particles contribute to superior flow.

Produces stable tablets, similar to Microcrystalline Cellulose, with almost no change in hardness, thickness or weight in testing
Spherical shape for excellent flow
Improves tableting of lower density materials
Low Hygroscopicity
Excellent disintegration and mouthfeel for chewables

Tolerates Variability in Lubricant Levels

Advantose 100 Maltose's excellent tableting characteristics are not diminished by use of lubricants nor extended mixing times. Advantose 100 had only a minor drop in tablet hardness when up to 1% Mg stearate was incorporated (Figure 1). Mixing times of up to 15 minutes were tested and had no significant detrimental effects on compressibility at all lubricant levels (Figure 2).

Figure 1: Tablet Hardness vs Compression Force For Various Lubricant Levels

Chart showing tablet hardness for various lubricant levels

Figure 2: Tablet Hardness vs Compression Force For Various Mixing Times

Withstands high compression

When compared to products like Avicel™ PH102, Advantose 100 will withstand the same or higher compression forces without capping on ejection from the tableting dye. In formulations tested by SPI Pharma, MCC capped in the range of 4000 lbs. Whereas there was no capping up to 8000 lbs, the maximum pressure tested, with Advantose 100 (Table 1).

Table showing Advantose compared with MCC during compaction