4 Reasons to Use Mannitol in Your Formulation
Mannitol is an inert carrier
Mannitol doesn’t promote acid-base reactions, oxidation, or react with primary amines.
It has high solubility
Mannitol is highly wettable and can decrease disintegration time, assisting the drug release. It can also improve the solubility of poorly soluble APIs.
Mannitol is non-hygroscopic
Meaning an increased protection against moisture in formulations, an improved chemical/physical stability of formulation and a protection of hydrolysable/moisture sensitive actives.
Mannitol can be used as a crystal in crystal solid dispersion