TAP® Tartaric Acid Spheres

TAP® pellets are spherical cores made of tartaric acid.   They are manufactured to be highly spherical, and high quality.  These materials are a solubility enhancement solution for drugs that exhibit poor solubility in alkali environments.


SPI Pharma's tartaric acid pellets are manufactured for SPI using TAP® processes from Advanced Drug delivery Technology, ltd.  This ensures robust mechanical stability and the highest consistency and quality.



Spherical tartaric acid starter cores are emerging as a critical tool in the solubility enhancement toolkit for drug formulators   Engineered for effective loading and coating, TAP® pellets can be coated with an API that exhibits pH dependent solubility.  TAP® spheres can create an acidic micro-environment for the drug coating to improve solubility, release, absorption, and efficacy.


Product Properties


TAP 200

TAP 300

TAP 400

TAP 500

TAP 600

TAP 700

Particle size distribution (≥ 85 %)

100-350 µm

200-355 µm

300-500 µm

400-600 µm

500-700 µm

600-800 µm

Additional Properties

Bulk density  Ph.Eur.

0.8-1.1 g/ml

Identification A, solution strongly acidic  Ph.Eur.

strongly acidic

Identification B, reaction of tartrate  Ph.Eur., USP/NF


Identification C, infra-red absorption  USP/NF

IR-spectrum equivalent reference standard

Appearance in solution  Ph.Eur.

clear and not more intensely colored than the reference Y6

Water content  Ph.Eur.

≤ 0.5 %

Loss on drying  USP/NF

≤ 0.5 % (for information only)

Calcium  Ph.Eur.

≤ 200 ppm

Chloride  Ph.Eur.

≤ 100 ppm

Specific optical rotation  Ph.Eur., USP/NF

+12.0° to +12.8°

Limit of oxalate  USP/NF

no turbidity

Residue on ignition  Ph.Eur., USP/NF, JP

≤ 0.05 %

Sulfate  Ph.Eur., USP/NF, JP

≤ 150 ppm

Heavy metals  Ph.Eur., USP/NF, JP

≤ 10 ppm

Arsenic  JP

≤ 1 ppm

Assay  USP/NF

99.7 % to 100.5 %


less than 1000 CFU/g


less than 100 CFU/g
E.coli  Ph.Eur., USP/NF, JP absence in 1 g sample